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Prior efforts to treat obesity demonstrate that sustained weight reduction is a Herculean task--thus it may be the case that GLP-1 agents will need to be administered chronically to sustain anti-obesity benefits

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In severe selenium deficient areas use a calculated dose of 0.1 mg selenium per kg bodyweight (i.e

The combination achieved 20.4% mean body weight reduction from baseline to week 68 (22.7% under the trial product estimand that accounts for discontinuation)

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