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The research, published on November 13 in The study, which included around 228,000 people in Sweden, showed a 36% lower risk of hospitalization among those taking semaglutide

Notably, astrocytes exhibit high Nrf2 activity, whereas neurons rely on astrocytic Nrf2-mediated protection

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Furthermore, NRF2 controls genes encoding enzymes governing different metabolic pathways, such as lipogenesis and lipid degradation, lipid transport and uptake, enzymes of the pentose phosphate pathway, and some enzymes of glycogen metabolism, like glycogen branching enzyme (GBE) and phosphorylase b kinase subunit A1 (PHKA1), recently linked to NRF2 signalling in the muscle [165] (Fig