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10.1097/CCM.0000000000001422 106 LamontagneF.MasseM

Cysteine 467 of the ASCT2 amino acid transporter is a molecular determinant of the antiport mechanism

Hydrogen water addresses these limitations through multiple complementary mechanisms: Supporting SOD expression through Nrf2 pathway activation Neutralizing hydroxyl radicals that form when SOD is insufficient Reducing overall oxidative burden to prevent SOD depletion Providing protection in tissues where SOD activity is compromised For individuals with SOD deficiencies, a combined approach may be optimaladdressing nutritional needs for SOD cofactors while using hydrogen water to provide additional antioxidant support through different mechanisms

Together, they are commonly used to maximize the body's natural growth hormone pulses while maintaining a favorable side effect profile

FDA-approved indications and formulations differ by product