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doi: 10.1016/j.archoralbio.2016.12.014 82 SpaggiariL.PedrettiN.RicchiF.PinettiD.CampiscianoG.De SetaF.et al

Parkinsons disease (PD) is a neurodegenerative disorder characterized by motor symptoms, including tremor, rigidity, and abnormal gait

The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence

Orforglipron (LY3502970), a novel, oral non-peptide glucagon-like peptide-1 receptor agonist: a phase 1a, blinded, placebo-controlled, randomized, single- and multiple-ascending-dose study in healthy participants