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These NPs are in situ capped with GSH, a biocompatible molecule with amino and carboxylic terminal groups for subsequent crosslinking processes [37,38,39]
MTHFR C677T T/T reduces enzyme activity by approximately 70% at physiological folate concentrations, impairing methionine regeneration and SAM production
Technical Challenges Oxidative Degradation: The peptide degraded within 14 days under standard accelerated aging conditions (40C)
Future trials should prioritize adaptive designs to evaluate combinations (e.g., NOX inhibitors + Nrf2 activators) and digital health tools (e.g., continuous glucose/BP monitoring) for dynamic OS assessment
10.1038/nature04673
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