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It is linked to elevated levels of fibrinogen and C-reactive protein, diabetes, insulin resistance, dyslipidemia, and hypertension, all of which raise the risk of CVD events ( It is less evident how GLP-1 agonists directly affect arrhythmias, some studies suggest they may reduce frequency of arrythmias because their favorable effects on metabolism and over all cardiovascular health

& Moon, J

There is no required washout period between stopping phentermine and starting a GLP-1, though your physician may want to confirm that cardiovascular parameters (heart rate, blood pressure) have returned to baseline before initiating new treatment

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Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin