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Over time, high blood sugar levels can cause damage to the nervous system, while medications prescribed to maintain blood sugar levels can also lead to B12 deficiency

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Neurogenic inflammation in acute migraine attacks is characterized by a TVS activation-induced release of neuropeptides, such as CGRP and substance P, from trigeminal nerve fibers at the dura, which causes increased vascular permeability, plasma protein extravasation, leukocyte infiltration, vasodilation, mast cell degranulation, activation of meningeal nociceptors, and the subsequent release of inflammatory mediators (5)

Guo Z, Yan M, Chen L, Fang P, Li Z, Wan Z, et al

Lazzerini and colleagues found that hyperhomocysteinemia is intricate in developing inflammation and autoimmunity (Lazzerini et al