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Likewise, loss-of-function mutations in another Ca 2+ -channel Transient receptor potential cation channel, subfamily M, member 2 (TRPM2) are also associated with human bipolar disorder and Trpm2 null mice display manic-like behaviours [29]

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However, despite their effectiveness, weight loss responses to single-agent GLP-1RAs may plateau over time, reflecting adaptive physiological mechanisms that counteract sustained energy deficit

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