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Obesity is a complex, multifactorial disease with genetic and environmental underpinnings, says Christopher McGowan, MD, a gastroenterologist, obesity medicine specialist, and founder of True You Weight Loss

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As a small molecule weighing approximately 529 Da, orforglipron binds to an allosteric pocket within the transmembrane domain of the GLP-1 receptor, stabilizing the active receptor conformation and driving downstream signaling through Gs protein coupling and cAMP accumulation