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In support of this observation, over expression of GS in a yeast model failed to increase GSH levels, whereas overexpression of GCL did [18]

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[11] Glutathione is maintained in the reduced form by an NADPH-dependent glutathione reductase and the ratio of reduced glutathione (GSH) to oxidized glutathione (GSSG) generally exceeds a value of 7

Various factors can induce changes in their chemical composition, morphology, and structure, thus altering their function