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Anxiety, irritability, and emotional activation are common during the first few weeks, particularly during dose adjustments

doi: 10.1681/ASN.2022030290 4 SolezKColvinRBRacusenLCSisBHalloranPFBirkPEet al

in retatrutide, this effect is thought to be offset by the concurrent GLP-1 and GIP receptor agonism, which promote insulin secretion

Semaglutide shows benefits beyond blood sugar control