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Moore has maintained a close eye on the evolution of the drugs, from lawsuits filed by manufacturers over compounded replicates to clinical trials of newer GLP-1 options at CU Anschutz

The problem is that most guides out there bury this information under pages of generic background, leaving researchers to piece together their own timelines from scattered clinical trial data and forum posts

Nature 364, 247249

The GLP-1 receptors on the choroid plexus, when activated, appear to decrease the rate of cerebrospinal fluid production

For those at high risk of NAION, alternative treatment options for diabetes and weight management may be considered