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Lingeman et al

The single compound addresses multiple aging concerns simultaneously

2.1 Given these gaps, we propose the following recommendations based on current evidence 2.1.1 For clinicians We propose a clinical medication use management process that encompasses review, screening, combination therapy, education, monitoring, and follow-up (Table 3)

For general skin anti-aging, systemic subcutaneous injection at 1 to 2 mg/day combined with topical application achieves the best tissue-level collagen response

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