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[PUBMED Abstract] Gerstenblith MR, Shi J, Landi MT: Genome-wide association studies of pigmentation and skin cancer: a review and meta-analysis

Int J Clin Pharmacol Res 1995

Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth

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