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Investigating incretin-based therapies as a novel treatment for depression in type 2 diabetes: findings from the South London Diabetes (SOUL-D) Study

Ipamorelins structure - Aib at the N-terminus and D-isomers at positions 3 and 4 - produces robust GH release through GHSR-1a while minimizing those off-target effects, letting researchers isolate GH-specific responses from confounding hormonal changes

They found butyric acid to be the main metabolite in middle-aged mice, whereas the fecal level of propionic acid showed an age-dependent decrease

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