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For individuals with Wilson's disease (a genetic disorder causing copper accumulation) or other copper metabolism disorders, theoretical caution is warranted, though even in these populations topical GHK-Cu is unlikely to pose significant risk given the minimal systemic absorption

This was particularly significant for R

The results of GPx activities in plasma in both Crohns disease (CD) groups as well as controls did not reveal any statistically significant differences [47]

Studies suggest that the copper(II) ion is essential for biological activity, as the apo-peptide (GHK without copper) shows reduced activity

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