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doi: 10.1530/REP-15-0403 63 MartnezPProverbioFCamejoMI

These residues can undergo oxidation to form disulphide bonds and thus reduce PDI or an equivalent ER oxidoreductase

Inhibition of tyrosinase (the key enzyme of melanogenesis): Direct inhibition: Thiol group binding with the copper-containing active site of the enzyme Indirect inactivation: Exerted via the antioxidant effect of glutathione that leads to quenching of free radicals and peroxides Switching production of eumelanin to phaeomelanin Modulation of the depigmenting properties of other antimelanogenic principles Table No * N * F * 100] / W Where VU = Titrant volume of sample (ml) Vb = Titrant volume of blank (ml) N = Titrant Normality F = Equivalence Factor W = Weight of Sample (mg) Acceptance Criteria: 98.0% - 101% on the dried basis

UV Protection & Sun Damage Defense One of the biggest advantages of astaxanthin over glutathione is its ability to act as a natural internal sunscreen