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However, a third of high-dose patients experienced nausea while 24% experienced vomiting, compared with 10.4% and 3.5% respectively for the placebo group

Restraints - High Cost of Therapy The high cost of therapy is a significant restraint for the GLP-1 receptor agonist market, limiting patient access and long-term adoption

This recognition changes the strategic landscape

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Endocannabinoid-mediated long-term plasticity requires cAMP/PKA signaling and RIM1