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doi: 10.3390/ijms21228551 79 PhadnisVVSniderJVaradharajanVRamachandiranIDeikAALaiZWet al

4-HNE represents a highly reactive lipid peroxidation byproduct that induces cellular damage by interacting with proteins, DNA, and other cellular components through iron- and oxygen-mediated chain-breaking reactions ( The transient receptor potential channel TRPM4 has been shown to promote ox-LDL-induced dysfunction in HCAECs through ferroptosis mechanisms ( Additionally, reduced sterol regulatory element-binding protein 1 (SREBP-1) expressiona key transcription factor in lipid and cholesterol metabolismis associated with stable CAD development

Its perfectly fine for a single-use application where you intend to use the entire contents of the vial immediately after reconstitution

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The cerebellar cortex appeared to be the most affected, and the cerebral cortex was the least affected