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Water retention or mild bloating: Small amounts of fluid retention can occur when starting peptide analogues of growth hormone because growth hormone causes sodium and water retention in the tissues, resulting in slight puffiness or bloating
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Epithelial membrane permeability and intestinal absorption can also be challenging for peptide therapeutics, but several technical strategies have been developed to improve the permeability and absorption of oral peptides, which have been the subject of several prior review articles [1719, 58, 7173]
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