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NAD has been demonstrated to achieve mitochondrial and DNA repair as well as lengthen Telomeres which may lengthen lifespan

(8) Furthermore, FOXO4's role in the IIS pathway suggests it might modulate the actions of diet and environmental factors on cell aging, acting as a mediator between external factors and cellular longevity pathways

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doi: 10.3889/oamjms.2018.313 105

In this review, we have summarized and outlined the recent advancements, mechanisms, prospects, and challenges of GSH-responsive and -exhausting metal nanomedicines from different strategies