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The immune system then mounts a defense, only this defense goes overboard and causes a bigger reaction than what is considered normal

f , Uptake of [ 13 C 2 , 15 N]-GSH (5 mM, top) or [ 13 C 4 , 15 N 2 ]-GSSG (0.5 mM, bottom) into mitochondria isolated from HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA for 10 min

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This intracrine pathway operates independently of PTH and is instead driven by local inflammatory mediators such as interferon- (IFN-) and lipopolysaccharide (LPS) [96, 99]