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Taken together, these observations may provide one explanation why hypoalbuminemia and inflammation so strongly correlate with cardiovascular mortality in both the general population 477,478 and CKD patients

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This imbalance could increase GLUT-4, VEGF, and PPAR- activity, leading to the overgrowth of adipose tissue seen in lipedema

The condition not only diminishes physical function, social well-being, and societal participation but also imposes substantial economic burdens on patients families and society at large