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Enhances Mood and Mental Health: B12 plays a role in synthesizing neurotransmitters, which can improve mood and reduce symptoms of depression and anxiety

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As for chaperon therapy, only patients with mutant forms amenable to Migalastat, mainly missense mutations that result in misfolded -Gal A and premature degradation of the protein, are potential candidates for this treatment option [6]

During this phase, matrix metalloproteinases (MMPs), primarily MMP7 , 10 and 11 , play a critical role in the degradation of the extracellular matrix (ECM) resulting in loss of structural integrity and tissue breakdown [11, 12] (Fig