Health Affairs (Project Hope), 43 (11), 14911501
The figures below reflect the approved label and published trial conventions and are provided strictly for research and educational reference not medical advice or a recommendation to self-administer

After maturation, MSTN is expressed in various tissues,[12,20,21] with the highest levels in skeletal muscle and lower levels in visceral and subcutaneous fat,[21] as well as cardiac muscle.[20] MSTN has also been reported to negatively regulate adipocyte differentiation and lipid accumulation by suppressing the expression of key transcription factors such as peroxisome proliferator-activated receptor (PPAR-) and CCAAT/enhancer binding protein-.[22] However, Mstn / mice exhibit significantly reduced fat accumulation under normal aging conditions despite a lower metabolic rate, [23] whereas a genetically obese mouse model shows elevated MSTN mRNA levels compared to wild-type mice, suggesting a positive correlation between MSTN expression and fat mass.[21] These findings have paved the way for MSTN to become a therapeutic target not only for muscle atrophy, but also for diabetes and obesity
Do not freeze the reconstituted solution
Zepbound joins Wegovy as the second incretin-based therapy for chronic weight management