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Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on August 11th, 2023

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It was demonstrated that metformin led to a protective effect against the development of PD by different mechanisms including inhibition generation of -synuclein, production of oxidative stress, attenuation of mitochondrial dysfunction, and modulation of the autophagy process through the AMPK-dependent pathway