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Further, few studies reporting the adverse events of PPIs have attempted to balance the corresponding benefits of PPI use with its purported harm

Kim EY, Schrader N, Smolinsky B, Bedet C, Vannier C, Schwarz G, et al

In laboratory testing, it did not inhibit related SAM-dependent methyltransferases or interfere with other enzymes in NAD+ salvage pathways

One was a clinical study in humans

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