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its decline impairs concentration and mental sharpness Weight gain Particularly visceral abdominal fat, driven by reduced estrogen, insulin sensitivity changes, and lower metabolic rate Benefits of Female HRT When hormones are restored to optimal physiological levels not just the bottom of the "normal" range the improvements are often transformative

doi: 10.3390/MOLECULES23020509 317 Fernandez-GilBAbdel MoneimAEOrtizFShenYQSoto-MercadoVMendivil-PerezMet al

Validation of high performance liquid chromatography-electrochemical detection methods with simultaneous extraction procedure for the determination of artesunate, dihydroartemisinin, amodiaquine and desethylamodiaquine in human plasma for application in clinical pharmacological studies of artesunate-amodiaquine drug combination

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Apelin/APLNR pathway Apelin (APLN) is an endogenous peptide-ligand of the G protein-coupled receptor APJ (APLNR) [171]