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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11
While NRF1 and NRF2 are differentially regulated by KEAP1 60 , both have overlapping targets and roles in preventing liver-related diseases 61
Cheng CK, Wang N, Wang L, Huang Y
Global programmed switch in neural daughter cell proliferation mode triggered by a temporal gene cascade
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