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Precision medicine review: rare driver mutations and their biophysical classification

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Typically, increased NADPH, which reduces glutathione, is able to compensate for elevated levels of oxidative stress caused by such triggers

A closely related value of 2.7 0.4 mol min 1 mg 1 was calculated on the basis of the well-established L-carnitine depletion assay (Figure 3A) [previously calculated value of 771 nmol min 1 mg 1 (Massmig et al., 2020)]