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[81] [111] Biochemistry [edit] Coenzyme function [edit] Vitamin B 12 functions as a coenzyme, meaning that its presence is required in some enzyme-catalyzed reactions

In some cases, a long term B12 deficiency can be responsible for permanent neurological and nerve damage

Copper serves as the functional engine of the peptide, driving enzymatic reactions that influence everything from collagen synthesis to vascular development

The Ontario Drug Benefit (ODB) database was used to identify patients who were prescribed vitamin B12 injections, and the Ontario Health Insurance Plan database was used to identify all physician claims for intramuscular injections as well as laboratory tests assessing vitamin B12 levels