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Loss of farnesoid X receptor (FXR) exacerbated the ferroptosis signaling pathway by enhancing iron accumulation, increasing lipid peroxidation, decreasing GSH levels and reducing GPX4 expression in cisplatin-treated mice and HK-2 cells [175]

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As showed in Figure 1F, GLP-1 was decreased significantly in T2D group

Furthermore, positive correlations among the sputum NSPs were observed at baseline and in response to treatment at all time points, pointing to the interrelated efficacy of brensocatib on all three NSP activities (202)