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doi: 10.2337/diab.45.6.832

This effect was mediated by the upregulation of PKA/CREB signaling and the downregulation of the Notch/Hes-1 pathway, leading to enhanced peroxisome proliferator-activated receptor coactivator 1 expression, thus improving gentamicin-induced renal injury in rats (115)

The possibility that GLP-1 receptor agonists may be effective for some substance use disorders is promising, but we need large randomized controlled trials to confirm benefit and clarify for whom they work best, he says