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3.1.2 Safety In total, 21 TEAEs were reported in 11 participants: 14 events were reported in eight participants (57.1%) with normal renal function, two in one participant (14.3%) with mild renal impairment, and five in two participants (28.6%) with moderate renal impairment (Table 3)
cAMP Microdomains and EPAC Signaling Beyond PKA, elevated cAMP activates Exchange Protein directly Activated by cAMP (EPAC2) in beta-cells
In the DURATION-8 study, the SGLT2i dapagliflozin was used in combination therapy with exenatide and showed reductions in HbA1c, systolic blood pressure, and blood glucose, with improved weight loss, when compared to monotherapy [93]