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Though its protein quality is poor, hydrolysis of sorghum protein by alkaline protease can result in peptides with higher antioxidant and ACE-inhibitory activity (Jia et al., 2019)

Key Takeaway: The form of the glutathione (L vs Reduced) matters less than the delivery system

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

This pronounced gradient renders GSH an effective and sensitive trigger for redox-responsive drug delivery systems