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It is not clear how GLP-1 signaling leads to the PI3-kinase activity seen in -cell proliferation

The dual action of tirzepatide on both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors amplifies appetite suppression but may also intensify autonomic nervous system effects

DOI: 10.1097/PAS.0b013e3182a0a150 46

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