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In addition, the latest guidelines classify microglial states into five major phenotypes: homeostatic, DAM-like, HLA/MHC class II, CRM or inflammatory, and interferon (IRM or IFN) clusters [105]

In the prefrontal cortex, increased TDO and KMO expression alongside reduced IDO and KAT shifts metabolism toward QA production, while cerebellar KYNA levels inversely correlate with symptom severity, linking KP dysfunction to 5-HT metabolism and clinical features [235]

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis

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Its primary role, as the name suggests, is to stimulate growth, cell reproduction, and regeneration