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Indirect effects are mediated mainly through IGF-1 (insulin-like growth factor 1), which is produced in the liver and other tissues in response to GH boost

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In the late endosomes and lysosomes, accumulation of Mn 2+ may be obtained through the cation transporter ATP13A2 (PARK9), which has been identified as fundamental to prevent manganese toxicity, and proposed to shuttle manganese and other cations from the cytosol into the lysosomal lumen (Schmidt et al., 2009

Phase 2 dose-finding data The phase 2 trial tested cagrilintide at 0.3 mg, 0.6 mg, 1.2 mg, 2.4 mg, and 4.5 mg weekly