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PMID: 238 Hossam AbdelmonemBAbdelaalNMAnwerEKERashwanAAHusseinMAAhmedYFet al

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An in vitro approach to detect metabolite toxicity due to CYP3A4-dependent bioactivation of xenobiotics

Remarkably, ER-, but not ER-specific ligands, lead to increased phosphorylation of ERK 1/2, which initiates cell cycle entry (demonstrated by the up-regulation of mitotic markers such as CDK1/cdc2 and PCNA), DNA replication, and duplication of the centrosome -the major microtubule-organizing center in the cell- in dividing cells (Wang et al., 2008)

Because Sermorelin works by stimulating the pituitary to release its own growth hormone, it was also paired with a diagnostic version ( Geref Diagnostic ) that helped determine whether the pituitary could respond appropriately before treatment was started