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The SURMOUNT-4 trial assessed the weight maintenance with tirzepatide and had also two periods: a 36-week open-label lead-in period during which all participants took tirzepatide, followed by a 52-week double-blind treatment period during which participants were randomised to either continue on tirzepatide or switch to placebo

The results of both animal and cellular studies have demonstrated that in the context of hyperglycemia, the hearts capacity to utilize glucose is diminished, which in turn promotes oxidative stress and inflammation in myocardial cells

This clinical success has translated into major commercial growth

Iron overload as a risk factor for hepatic ischemia-reperfusion injury in liver transplantation: potential role of ferroptosis

Strengthened immune system