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Crosstalk Between Metabolic Regulators and Metastatic Pathways Intrinsic Factors: Tumor-related Genes that Regulate Metabolic Pathways in Breast Cancer Metastatic Cascade TP53 TP53 mutations are very common in breast cancers, especially in triple-negative and HER2-positive subtypes (155)

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These results reveal the dynamic interplay between the structural states of the CRL4 DET1-COP1 E3 ligase complex and its substrate specific activation mechanism, offering mechanistic insights into ubiquitination regulation and a basis for future studies on E3 ligase dynamics

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