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Inhibition of the plasma membrane L-type Ca 2+ channels results in reduced intracellular Ca 2+ concentration which reduces the capacity to activate myosin light chain kinase, a key enzyme in the contractile activity of smooth muscle

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Nevertheless, transplacental passage is rapid, and fetal levels approach maternal concentrations within minutes, raising concerns when prolonged infusions are contemplated

Dogs with exocrine pancreatic insufficiency should be considered at high risk for the development of cobalamin deficiency