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Samuels, a professor at the Oregon Clinical and Translational Research Institute, stated: It is a common clinical observation that some otherwise healthy patients with hypothyroidism continue to complain of fatigue, poor mood, inability to concentrate, and vague cognitive difficulties (often described as brain fog) despite normal TSH levels. [5] 2

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It has been shown that roGFP2 is almost fully reduced in intact tissues and that a treatment with the GSH1 inhibitor BSO or the electrophilic xenobiotic 1-chloro-2,4-dinitrobenzene led to fully oxidized state of the biosensor accompanied by decreased fluorescence intensity 52