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When examining a composite cardio outcomes endpoint (death from CV disease, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina), the ELIXA trial suggested that GLP-1s did not increase cardiovascular event risk (hazard ratio of 1.02)

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However, they can play a role in the transition to retatrutide, as some patients may notice changes in their side effect patterns during the switch

Figure 8 Headache According to the study, headaches were more common in the ROSE-010 treatment group (100 g) than in the placebo group

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