This assessment enables us to create a customized treatment plan that considers not just the medication but also lifestyle changes, nutritional support, and ongoing guidance
Cardiovascular outcomes trials for tirzepatide are ongoing, including SURMOUNT-MMO (NCT05386329), which is evaluating cardiovascular outcomes in patients with obesity and established cardiovascular disease
People who find exercise difficult due to fatigue may find the semaglutide fatigue guide helpful, as fatigue management often comes down to electrolytes and meal timing rather than the medication itself
Comparisons Of Efficacy And Safety Between Oral Semaglutide And Other Comparators (Empagliflozin, Sitagliptin) The glycemic effects of oral semaglutide are at least comparable to other oral antidiabetic drugs and may even be superior
Ancillary and post-trial care Post-trial care of the participants will include treatment with metformin in line with the latest international guidelines that advise a consideration of metformin as an adjunct to lifestyle intervention in adult women with PCOS with body mass index (BMI) 25 kg/m 2 , regardless of the presence of glucose disturbances and menstrual irregularity, for the management of weight and preventing or slowing progression to adverse cardiometabolic outcomes [21]
