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In case of overdose, the sulphate and glucuronide pathways become saturated, and more paracetamol is shunted to CYP450 system to produce NAPQI

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Bradnam LV, Frasca J, Kimberley TJ

Final recommendations depend on medical history, wellness goals, treatment response, pharmacy availability, and clinical appropriateness

Serotonin also plays a role in the CNS and controls many stress mechanisms such as the HPA axis through stimulation of corticotropin-releasing hormone (CRH) (432)