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After getting a B12 shot, you should watch out for these symptoms and see a doctor if you have: Strong pain where you got the shot Some stomach upset Feeling swollen Skin feeling itchy for a while In really rare cases, there might be more serious risks like: A severe allergic reaction called anaphylaxis Fluid build-up in the lungs Heart problems Blood clots in the bodys blood vessels A type of blood cancer, called polycythemia vera