Strategic focus on comorbidity management positions GLP-1s as comprehensive metabolic disease agents
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The peptide works specifically on adipose tissue through beta-3 adrenergic receptor modulation, triggering lipolysis while inhibiting lipogenesis, without affecting growth hormone levels, insulin sensitivity, or other metabolic systems
It is studied in preclinical models to investigate mitochondrial biogenesis enhancement, cellular energy metabolism regulation, neuronal metabolic support, and potential cognitive effects
But Wegovy and Eli Lilly's Zepbound were approved only as anti-obesity drugs, until the FDA's recent expanded approval for Wegovy