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Closing K + channels causes depolarization, allowing Ca ++ entry to stimulate insulin secretion

Interestingly, men with distal chromosome 15 structural abnormalities are more likely to experience cryptorchidism, and this appears to involve the IGFR locus (92)

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[PubMed: 9554492] 247

Our findings represent an early effort to identify traits of patients most likely to benefit or be harmed by medications, which can eventually assist in establishing effective criteria or algorithms to determine which patients may benefit in clinical settings, i.e., precision medicine