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Bulk RNA-sequencing of liver and WAT RNA extraction, library construction and sequencing To assess changes in gene expression in peripheral tissues, liver and inguinal WAT collected from DIO Gipr Syn/ and Glp1r Wnt1/ mice with mGIPR-Ab/P1 peptideantibody conjugate treatment (Figs

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For drug development, the GLP-1 receptor agonist structure should also be considered, since ligand orientation, peptide modifications, and half-life-extending features directly influence pharmacokinetics and receptor interactions

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Unfortunately, glutathione can leak from microsomes, altering the [GSH]:[GSSG] ratio during their preparation, which would affect the values